Supported

What the evidence supports

  • Semaglutide and tirzepatide act on hormone pathways involved in appetite, food intake, and blood sugar regulation.
  • Weight management medications are meant to be used alongside diet and physical activity, under a provider's care.
  • Medication works best as part of a broader plan that includes balanced nutrition, physical activity, hydration, sleep, and ongoing medical support.
Less clear

What to keep in mind

  • Compounded semaglutide and tirzepatide are not FDA-approved and have not been reviewed by the FDA for safety, efficacy, or quality.
  • Responses differ. Some people lose substantial weight, some lose less, and some cannot tolerate a particular medication.
  • Some weight regain is common after stopping, so treatment may need to continue over the long term to maintain its benefits.
Our position

What we tell people

  • Successful weight management is not just about losing weight. It's also about supporting overall health, maintaining muscle and physical function, and building sustainable habits.
  • Medication may be part of that process, but it is not a magic fix.
  • We explain what the research supports, what the risks are, and what questions to discuss with your healthcare professional, without exaggerated promises or one-size-fits-all recommendations.
  • Less hype. More clarity. A more informed approach to weight management.

A provider will not prescribe if you have

  • A personal or family history of medullary thyroid carcinoma (MTC).
  • A personal history of multiple endocrine neoplasia syndrome type 2 (MEN2).
  • Type 1 diabetes.
  • Being under 18.

Tell your provider if you

  • Are pregnant, planning a pregnancy, or breastfeeding. These medications are not intended for weight loss during pregnancy. Discuss timing and contraception with your provider before treatment.
  • Have a history of pancreatitis, gallbladder disease, or severe digestive problems.
  • Take insulin, medicines that can cause low blood sugar, or other weight loss medications.
  • Have other medical conditions or take prescription medications or supplements.

Not sure whether something applies to you? Start the consultation anyway. A licensed provider reviews every answer and will tell you plainly if a GLP-1 isn't a fit.

Urgent

Stop and get help right away

Severe or persistent abdominal pain, especially if it radiates to your back
Possible pancreatitis. Seek care right away.
Repeated vomiting or being unable to keep fluids down
Risk of dehydration and kidney problems. Seek care right away.
Trouble breathing, or swelling of the face or throat
Possible serious allergic reaction. Call 911.
Other severe or rapidly worsening symptoms
Seek prompt medical care.
Common

Expected, no action needed unless it lasts

Nausea
Common, especially when starting or increasing the dose
Often eases as your body adjusts.
Diarrhea or constipation
Common
Stay hydrated. Mention it if it lasts.
Vomiting
Common early on
Seek care if you can't keep fluids down.
Abdominal discomfort
Common
Usually mild. Severe pain is urgent.
Reduced appetite
Expected
Still aim for enough protein and fluids.
Mention it

Tell your provider at your next check-in

Side effects that are persistent or interfere with eating or drinking
Your provider may adjust the dose or schedule.
Appetite so low that it's hard to eat enough
Your nutritional needs should be individualized.
Pain in the upper right abdomen
Possible gallbladder problem. Contact your provider promptly.
First weeks

Starting low

Treatment typically starts at a lower dose and increases gradually as directed by your prescriber. This helps your body adjust and can reduce gastrointestinal side effects.

Weeks 2 to 8

Appetite changes

Some people notice changes in appetite within the first few weeks, while weight changes take time.

Months 2 to 6

Dose increases

Doses are often increased gradually, so the early treatment period is not necessarily an indication of your eventual results.

Ongoing

A long-term plan

Some weight regain is common after stopping. Discuss long-term treatment, alternatives, and follow-up with your provider before stopping.

Monitoring

Your provider decides whether you need labs and when, based on your health history. Never increase your dose or change your schedule without guidance from your prescriber. Adequate nutrition, sufficient protein, resistance exercise, and clinical monitoring can help support muscle during weight loss.

$239
per month and up (includes provider review, medication and shipping). Cash-pay, no insurance claims.
$0
charged if a provider doesn't prescribe. The hold is released.
48 hrs
Cancel at least 48 hours before your next billing date. Any charge after a successful cancellation is refunded.